JMML may mimic or manifest itself after a viral infection so is important to exclude an infection and integrate all clinical and laboratory information (morphology, histology, genetics, and flow cytometry) in order to ensure a reliable diagnosis. Patient is waiting for compatible donor for allogeneic HCT.ĭue to the rareness and unspecific characteristics of JMML, frequent mistakes and a delay in diagnosis occur. Individual MPA through concentrations were accessed using high-performance liquid chromatography (Argilent ®, 1100 series), and were classified into sub-therapeutic (≤ 1.9 mg/L), therapeutic (> 1.9 mg/L, 1×10 9/L, <20% blasts in PB or BM, absence of BCR-ABL fusion gene and clinical diagnosis of NF1. Clinical and laboratorial data including anthropometric data and glomerular filtration rate (eGFR) were obtained from patients electronic charts. Materials and Methods: we conducted a cross-sectional study enrolling 58 kidney transplant recipients with more than 6 months of follow-up, receiving MPA in a steady dose (500 + 500 mg). The aim of this study was to determine if MPA through concentrations in kidney transplant recipients are in therapeutic levels and clarify if therapeutic drug monitoring of MPA should be considered. There is growing evidence supporting the notion that there is substantial variability in the intra and interpatient exposure to MPA 2. Introduction: mycophenolic acid (MPA) is widely used as an antirejection drug after renal transplantation 1. Mafalda Felgueiras 1, Margarida Pereira 2, Henrique Reguengo 3, Luísa Carvalho 3, Helena Martins 3, José Carlos Oliveira 3ġClinical Pathology Service, Centro Hospitalar do Cova da Beira – Covilhã ĢClinical Pathology Service, Unidade Local de Saúde de Matosinhos – Matosinhos ģClinical Pathology Department, Centro Hospitalar da Universidade do Porto – Porto. Henrique Reguengo P01 RELEVANCE OF THE THERAPEUTIC MYCOPHENOLIC ACID MONITORING IN KIDNEY TRANSPLANT
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